Silica encapsulated SERS nanoprobe conjugated to the bacteriophage tailspike protein for targeted detection of Salmonella.

نویسندگان

  • Li-Lin Tay
  • Ping-Ji Huang
  • Jamshid Tanha
  • Shannon Ryan
  • Xiaohua Wu
  • John Hulse
  • Lai-Kwan Chau
چکیده

Silica-encapsulated Raman-reporter embedded SERS nanoprobes, named nanoaggregate embedded beads (NAEBs), were conjugated to the Salmonella specific tailspike protein (TSP) isolated from the P22 bacteriophage to enable a highly specific and ultrasensitive optical transduction platform. We demonstrate three successful surface conjugation strategies and highlight the detection of a single bacterium using SERS.

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عنوان ژورنال:
  • Chemical communications

دوره 48 7  شماره 

صفحات  -

تاریخ انتشار 2012